The toll road was backed up for hours after two crashes that injured three people.
The first crash happened Friday afternoon when a truck ran off the road, slowing down traffic on the road.
While the traffic was slow moving, a pick-up truck crashed into the back of a semi truck.
Three people inside the pick-up truck were injured.
Emergency helicopters were called in and transferred the three individuals to a Kalamazoo hospital.
The road remained closed for several hours as they cleared the scene but eventually reopened.