Kayla McBride scored 19 points to help No. 2 Notre Dame beat Pittsburgh 73-47 on Wednesday night for the Irish's 12th-straight win.
Jewell Loyd added 14 points while Skylar Diggins had 13, all in the first half.
Diggins is one point shy of 2,000 for her career, she will look to reach that total Saturday at 2pm against Providence in front of her hometown crowd.
With the game tied at 29, Notre Dame scored the final six points before break. The Irish continued the spurt in the second half, scoring 25 of the first 28 points.
Notre Dame (17-1, 6-0 Big East) led 60-32 with 10 minutes left and coasted from there.
Brianna Kiesel scored eight points to lead Pitt (9-9, 0-5). The Panthers haven't won a Big East game since Feb. 15, 2011.
It was the first meeting between the two teams since Notre Dame dealt Pittsburgh its worst loss in program history, a 120-44 defeat on Jan. 17, 2012.