The Philadelphia Eagles are the latest team to be shredded by Peyton Manning and the Denver Broncos.
Manning completed 28 of 34 passes for 327 yards, four touchdowns and no interceptions as the Broncos crushed the Eagles 52-20 to improve to 4-0. Demaryius Thomas and Wes Welker each grabbed two scoring strikes from Manning, who's thrown 16 touchdown passes this season without an interception to tie the start of Cleveland's Milt Plum during the 1960 campaign. Welker has caught six of those TD tosses.
Manning also broke Brett Favre's NFL record with his 24th career game with at least four touchdown passes.
Michael Vick threw for 248 yards and no touchdowns for the Eagles, who've dropped three straight since an impressive season-opening win at Washington.
The Redskins finally picked up their first win as Robert Griffin III threw for 227 yards and one touchdown in a 24-14 win at Oakland. Washington scored the game's final 24 points and went ahead on Griffin's five-yard pass to Pierre Garcon with 2:58 left in the third quarter.
Matt Flynn was 21 of 32 for 227 yards but couldn't engineer a scoring drive after the first quarter for the 1-3 Raiders.
Who would have thought that after four weeks of play the Chiefs would be 4-0 and the Giants 0-4? That's the case following the Chiefs 31-7 win over the New Yorkers. Alex Smith threw three touchdown passes, Dexter McCluster returned a punt 89 yards for another score and the Chiefs, under new coach Andy Reid, doubled their victory total of 2012. The Giants, who trailed 17-7 after three quarters, are 0-4 for the first time since 1987. Eli Manning connected with Victor Cruz on a 69-yard scoring play for New York's only score. The Kansas City defense sacked Manning three times.
Reggie Bush's 37-yard touchdown run helped Detroit score 27 points in the second quarter. Bush accounted for 173 yards of offense to help the Lions beat the Bears 40-32. Each team is 3-1 and tied for the lead in the NFC North. The Lions scored 24 straight points, including three TDs in a span of 3 minutes, 26 second after Matt Forte's 53-yard TD run gave the Bears 10-6 lead early in the second quarter. Jay Cutler, who had four turnovers, threw a pair of touchdown passes and 2-point conversions in the final 4 minutes to pull Chicago within eight points to make the score look respectable.
Brian Hoyer is 2-0 as Cleveland's starting quarterback. The Browns beat the Bengals 17-6 as Hoyer threw two touchdown passes in his first start at home. His 1-yard TD pass to Chris Ogbonnaya (oh-bon-EYE'-uh) with 4:54 left gave the 2-2 Browns an 11-point lead before Cleveland turned it over to its vastly improved defense. Hoyer finished 25 of 38 for 269 yards In his second start in place of injured Brandon Weeden. The 2-2 Bengals couldn't get anything going on offense and Andy Dalton was intercepted by Buster Skrine with 3:43 left, ending any chance of a comeback.
The Vikings got their first win of the season by beating Pittsburgh 34-27 in London. Greg Jennings had two touchdown catches, Adrian Peterson ran for two scores and the Vikings' defense had a big stop with time running out to preserve the win. Everson Griffen stripped Steelers quarterback Ben Roethlisberger (RAWTH'-lihs-bur-gur) on the 6-yard line with 19 seconds left. Vikings quarterback Matt Cassel (KAS'-uhl), starting in place of injured Christian Ponder, finished 16 of 25 for 248 yards and two touchdowns.
The Steelers fell to 0-4 for the first time since 1968.
A 45-yard field goal by Steven Hauschka in overtime gave the Seattle Seahawks a 23-20 win over the Houston Texans and their first 4-0 start in club history. The 2-2 Texans failed to score on two possessions in overtime. The Seahawks got the win on their second drive in overtime after rallying from a 20-3 deficit.
Richard Sherman returned an interception 58 yards for a touchdown that tied the game 20-20 with less than three minutes remaining in regulation.
Rookie linebacker Kiko Alonso's second interception of the game for the Bills with 57 seconds remaining sealed a 23-20 win over the Ravens. Baltimore's Joe Flacco (FLAK'-oh) had a career-worst five interceptions in the game while Buffalo totaled 213 yards rushing against a stout Ravens defense that had allowed just 224 in its first three games.
Andrew Luck threw two touchdown passes and finished the day 22 of 35 for 260 yards as the Colts beat the Jaguars 37-3. Newcomer Trent Richardson also ran for a score for the Colts who are 3-1. The 0-4 Jags have been outscored 75-8 in the first half this season.
Philip Rivers was productive in San Diego's 30-21 comeback win over Dallas, completing 35 of 42 for 401 yards and three touchdowns. Antonio Gates had 10 receptions for 136 yards, including a 56-yard TD grab with 6:65 left.
Tony Romo passed for 244 yards and a pair of second-quarter touchdowns, both to Dez Bryant. But the Cowboys failed to score after Sean Lee's 52-yard interception return for a touchdown just before halftime.
Both teams are 2-2.
Tennessee turned Geno Smith's four turnovers into 28 points in a 38-13 romp over the New York Jets. Jake Locker threw a career-high three touchdown passes before suffering a right hip injury in the third quarter, sending him to a hospital.
Alterraun Verner intercepted two passes and recovered a fumble, and Ropati Pitoitua had two of Tennessee's five sacks as the Titans improved to 3-1.
Smith completed 23 of 34 passes for 289 yards, one touchdown and two costly interceptions for the 2-2 Jets.
The Cardinals roared back from a 10-0 halftime deficit to beat Tampa Bay 13-10. Carson Palmer threw a 13-yard touchdown pass to Larry Fitzgerald, then Jay Feely kicked a 27-yard field goal with 1:29 remaining as the Cardinals upped their record to 2-2. Feely also kicked a 42-yard field goal for the Cardinals.
The Bucs are winless in their four outings this season.