Paul George scored 31 points and David West had 20, leading Indiana past Houston 105-95 Friday night.
The Pacers (25-16) have won 11 straight home games - their longest streak since winning 14 in a row in 2002-03.
Houston (21-20) has lost six in a row. The Rockets were led by Omer Asik with 22 points and James Harden with 17.
But it was a big night for George, who made 8 of 11 shots and five 3-pointers during a 23-point first half that gave Indiana control.
Houston got as close as three early in the third, but Indiana went on a 10-3 run, closed the quarter on a 12-4 spurt to make it 83-69 and didn't let Houston get closer than seven the rest of the game.