Peyton Manning's near-perfect start to the season continued Sunday night as he had 309 yards and three touchdown passes, and the Colts never trailed in beating their AFC South rivals 31-9 for their NFL-best 14th straight regular-season win.
Manning joined Kurt Warner and Steve Young as the only NFL quarterbacks to open a season by throwing for at least 300 yards in the first five games. He will have to wait out a bye week to try and match them with a sixth such game.
Indianapolis (5-0) has not lost since its last visit to Nashville and leaves now with a firm grip on the AFC South that the Colts have controlled all but the two seasons Tennessee has won the division.
The Titans (0-5) have matched their 0-5 start in 2006. It got so bad that Jeff Fisher put in backup quarterback Vince Young in the fourth quarter.