Muffet's Squad led top-seeded Tennessee by two points at halftime, but Candace Parker led the Lady Vols on a 14-0 second half run as Tennessee eliminated Notre Dame from the NCAA Tournament with a 74-64 win in the Sweet 16 in Oklahoma City.
Tennessee is now 20-0 all-time against Notre Dame.
Parker, the nation's best player, scored a career high 34 points in the win. She scored Tennesee's first eight points in the game, but the Irish remained tied with Tennessee early.
Freshman Becca Bruszewski had a very strong game, scoring a career-high 16 points, even blowing by Parker early on to give the Irish a 16-12 lead.
Notre Dame extend the lead to eight at 22-14, before Parker led Tennessee back on a 8-0 to tie the game.
After a Lindsay Schrader bucket, the Irish took a two point lead into halftime.
Notre Dame opened the lead up to four early in the 2nd half, before Tennessee scored 14 unasnwered.
The Lady Vols pushed the lead to as many as 16 points in the 2nd. The Irish didn't give up, pulling back within single digits late in the game, but it wasn't enough.
Senior Charel Allen, who had an outstanding NCAA Tournament, scored 16 points in the final game of her career at Notre Dame.
The loss also ends the careers of Tulyah Gaines, Amanda Tsipis and Melissa D'Amico.
Tennessee advances to the Elite 8 and will face Texas A&M on Tuesday.