The Irish Icers earned the 4th seed in the West Regional and will face top-seeded New Hampshire Friday, March 28 at 6:30 EST in Colorado Springs.
The other Regional Semifinals will feature host Colorado College taking on Michigan State.
The two winners will play on Saturday, March 29 at 10 p.m. ET for the West Regional championship and the right to advance to the Frozen Four in Denver, Colo., on April 10 and 12.
For Notre Dame, this is the second consecutive year that the Irish have advanced to the tournament and the third time in the program's history.
In 2006-07, they were the tournament's top seed and defeated Alabama-Huntsville, 3-2, in double overtime in the opening game before falling to Michigan State in the Midwest Regional by a 2-1 score.
In 2003-04, Notre Dame made its first-ever appearance, dropping an opening round game to Minnesota, 5-2.
The Irish enter the tournament ranked 11th in the nation and are 24-15-4 overall, coming off a pair of 2-1 losses in the CCHA Tournament. The first 2-1 loss came in overtime in the semifinals to Miami and the second one came in the third-place contest to Northern Michigan.
New Hampshire was ranked fourth last week and finished the year with a 25-9-3 and was the regular-season Hockey East champion.
The Wildcats lost in the conference semifinals to Boston College, 5-4, in triple overtime on Saturday night.
For Notre Dame and head coach Jeff Jackson, the trip to Colorado Springs has an interesting twist, as the World Arena is where his first game as head coach of the Irish took place on October 21, 2005.
The Irish dropped a 3-1 decision to Colorado College that night but the Notre Dame program has come a long way in just three short years with Jackson leading the program.