Ashley Barlow scored 19 of her career-high 22 points in the second half and Notre Dame (No. 20 ESPN/USA Today, No. 16 AP) rallied to beat Purdue 61-48 on Saturday.
Charel Allen scored 10 points and Lindsey Schrader added eight points and 10 rebounds for the Irish (8-1).
Danielle Campbell had 13 points, seven rebounds and six blocks for Purdue (3-5), but she was 5- for-13 from the field. Kalika France scored 11 points and Lakisha Freeman had five points and 11 rebounds.
Notre Dame won its sixth straight and claimed its first win over the Boilermakers in nine tries at Mackey Arena. The Irish shot 52 percent from the field in the second half, while the Boilermakers shot just 26 percent.
Purdue has lost five of its past six, including all three matchups with ranked teams.
Purdue led 36-32 early in the second half before Barlow made back-to-back 3-pointers to give the Irish a 38-36 edge with 12:07 to play.
Barlow made another 3-pointer to give Notre Dame a 47-41 lead, then Devereaux Peters scored on a putback to make it 49-41 with 5:46 to play. The Irish led by at least six points the rest of the way.
Notre Dame led 15-14 before Purdue went on a 7-0 run, highlighted by a 3-pointer from France, to take a 21-15 lead with 4:48 left in the first half. The Boilermakers led 25-20 at halftime, despite shooting 36 percent from the field. The Boilermakers held Notre Dame to 35 percent shooting in the first 20 minutes.