USC and Notre Dame have played 79 times.
And Saturday proved to be the most lopsided Trojan win in the rivalry's historic history.
Troy came into South Bend and rolled over the Irish 38-0.
Notre Dame is now 1-7 on the season.
The game was scoreless in the 1st quarter when USC was forced to punt. The ball bounced off Irish player Munir Prince and the Trojans recovered at the Irish 10 yard line.
On the next play, Mark Sanchez hit Fred Davis for a touchdown to make it 7-0 USC.
Evan Sharpley, starting his first ever game in place of Jimmy Clausen, couldn't muster much. Sharpley was 17 of 33 for 117 yards, 0 touchdowns and 1 interception.
USC scored its second touchdown when Sanchez hit Allen Bradford for an 8-yd score in the 2nd quarter. Sanchez, starting his 2nd ever game, was 21 of 38 for 235 yards and four touchdowns.
USC led 17-0 at the half.
The Trojans busted the game open in the 3rd quarter.
After a Travis Thomas fumble, USC took over again inside the Irish 15.
Sanchez found Stanley Havili for a 5-yd touchdown to make it 24-0.
Four minutes later, Sanchez hit Vidal Hazleton with a pass and Hazleton took over busting one 48 yards for a touchdown.
In the 4th, Joe McKnight added a 51 yard touchdown run to seal the game at 38-0.
The Irish have a bye week coming up before three straight games, beginning with Navy in two weeks.