Brian Griese threw a 34-yard touchdown pass to Desmond Clark with 2:05 remaining to give the Chicago Bears a 27-20 win over the Green Bay Packers.
The Bears, who improved to 2-and-3, rallied from a 20-10 deficit by scoring 17 unanswered points.
Chicago clinched the victory when Brandon McGowan picked off Brett Favre in the end zone in the final seconds. It was Favre's second interception of the game and the 277th of his career, tying George Blanda's dubious career mark.
The Packers led 20-10 in the third quarter but Brian Urlacher picked off a Favre pass and on the next play, Griese threw a 19-yard scoring strike to Greg Olsen.
Early in the fourth quarter, Robbie Gould tied the score at 20 with 36-yard field goal.
The 4-and-1 Packers committed five turnovers.
The Indianapolis Colts didn't need Joseph Addai and Marvin Harrison in a 33-14 rout of Tampa Bay.
Kenton Keith rushed for 121 yards and two touchdowns while starting in place of Addai, who was out with a bruised shoulder. Keith ran for a seven-yard score that put the Colts ahead 23-7 midway through the third quarter.
Anthony Gonzalez led the Colts with 71 receiving yards on seven catches. Gonzalez started for Harrison, who missed the game with a bruised left knee.
The personnel moves didn't bother Peyton Manning, who was 29-of-37 for 253 yards, including touchdown throws to Dallas Clark and Reggie Wayne.
Bucs quarterback Jeff Garcia completed 18 of his 23 passes but finished with 143 yards. He hit Alex Smith for a pair of three-yard touchdowns.
The 5-and-0 Colts head into their bye week unbeaten for the third straight year.
The Bucs slipped to 3-and-2.
Indianapolis joined New England as the first NFL teams to reach the 5-and-0 mark. Tom Brady passed for 265 yards and three touchdowns as the Patriots doubled up Cleveland 34-17.
The Washington Redskins picked off two passes and forced a pair of fumbles while shutting down Detroit's high-scoring attack in a 34-3 rout of the Lions.
The Lions came away with just a field goal and 149 total yards after averaging 28 and a-half points and 387 yards a game. The only time Jon Kitna got his team into an end zone was when he was sacked for a safety.
Carlos Rogers returned one of Kitna's two interceptions 61 yards for the final touchdown.
Mike Sellers had two touchdowns for the 3-and-1 Redskins, who played without receivers Santana Moss and Antwaan Randle El in the second half. Jason Campbell didn't miss his two targets, completing 23 of 29 passes for 248 yards, two touchdowns and no interceptions.
Randle El had seven receptions for 100 yards before leaving with a hamstring injury just before halftime.
Kitna was limited to 106 passing yards for the 3-and-2 Lions.