Relieving chronic back pain without surgery


One-in-three people in the U.S. suffers with chronic pain.

It affects more Americans than diabetes, heart disease, and cancer combined.

Non-invasive treatments in the past have been limited, but now stem cells could hold the key to the future of pain management.

Bobby Sydnor and his band have something to sing about.

Bobby may have found the answer to his debilitating pain from a motorcycle accident 40 years ago that nearly crushed his spine, leaving him with three degenerative discs.

Has chronic back pain "It's just excruciating; it is. I remember sometimes crawling to the bathroom," says Bobby.

But now thanks to a cutting edge therapy, the bonsai enthusiast is finally getting some relief without surgery.

Doctor Tory McJunkin is involved in a multi-center clinical trial that's using stem cells to regenerate discs in the spine.

"It really has the potential to change the disease state, instead of just treating the symptoms,” explains McJunkin. “They have the ability to change and to regrow that tissue until it's a normal tissue.”

Preclinical studies on sheep showed their discs were regenerated-seen here.

"The treated disc looks exactly the same, you can't tell a difference at all and the untreated disc is very degenerative, very black,” says McJunkin.

Full human trial results will not be available until later this year, but in early data 71 percent of patients who received a low dose of stem cells showed a significant reduction in low back pain and improvement in function, compared with 20 percent of patients in the control group.

Now, two years into the study, Bobby says he's definitely feeling a difference and can't wait for what's next.

Fifteen sites across the country are conducting the trials.

Full results from the phase two trial are expected in the third quarter of this year.

The stem cells do not come from human embryos.

Instead, they're harvested from healthy adult donors.

MEDICAL BREAKTHROUGHS
RESEARCH SUMMARY

TOPIC: OH, MY BACK!
REPORT: MB # 3640

BACKGROUND: Back pain affects 80 percent of Americans at some point in their lives. In fact, back pain problems are the most common physical complaints among American adults and are a leading cause of lost job time. It can include sore tendons and muscles, fractures, herniated discs, and other problems. The most common back pain causes include nerve and muscular problems, arthritis, and degenerative disc disease. It is important to understand that back pain is a symptom of a medical condition; it is not a diagnosis itself. (Source: www.webmd.com)

MEDICAL PROBLEMS: Medical problems that cause back pain can include:
* Injuries-Spine injuries, like fractures and sprains, can cause short-lived or chronic back pain. Sprains are tears in the ligaments that support the spine, and they occur from lifting improperly. Fractured vertebrae are often from osteoporosis. Accidents and falls are also causes of back pain.
* Mechanical Problems-A mechanical problem is because of the way the spine moves or the way you feel when you move your spine in certain ways. One of the most common mechanical causes of back pain is a condition called intervertebral disc degeneration, meaning that the discs between the vertebrae of the spine are breaking down with age. (Source: www.webmd.com)

TREATMENT: Most back pain gets better with home treatment and careful attention. A short period of bed rest is recommended, but too many days can actually do more harm than good. When it is more severe, physical therapy is the cornerstone of back pain treatment. A physical therapist can apply a variety of treatments, like ultrasound, heat, electrical stimulation, and muscle-release techniques. If that doesn't work, injections are another option. The doctor may inject cortisone into the space around the spinal cord. (Source: www.mayoclinic.com)
NEW TECHNOLOGY: For some patients, traditional treatment just doesn't work. So, one of the newest breakthroughs in managing back pain is coming from stem cells. A company called Mesoblast released the latest news in a string of studies examining the ability of a specific type of stem cell to treat back pain. In the earliest tests, the company injected mesenchymal precursor cells (MPCs) into three adjacent lumbar discs in 24 adult male sheep. The sheep were injected with chrondroitinase in order to mimic disc degeneration and other discs were left alone. The degenerated discs had 45 to 50 percent less height before treatment with MPCs. After the discs were injected, they rehydrated and increased in height at statistically significant rates. Mesoblast has now released its second round of preliminary results from a phase 2 human study. For this phase, researchers injected allogeneic MPCs into damaged intervertebral discs. Researchers at IPM Medical Group in Walnut Creek, California; The Spine Institute in Santa Monica, California; Carolina Neurosurgery & Spine in Charlotte, North Carolina; Arizona Pain Specialists in Phoenix, Arizona; Virginia I-Spine Physicians in Richmond, Virginia, and Emory Orthropaedics & Spine Center in Atlanta, Georgia, report that a single low-dose injection of MPC significantly reduced low back pain in the treated patients and did so at a statistically significant way when compared to the control group. The study has enrolled 100 patients in 13 sited in the U.S. and Australia. At the six month follow-up, 71 percent of patients who received a low dose of MPCs met the pre-specified treatment success criteria. Twenty and thirty percent of the patients in the two control arms who received hyaluronic acid and saline met the pre-specified success criteria. (Source: http://ryortho.com/breaking/major-study-update-stem-cells-ease-back-pain/) "Stem cell research within the disc is very exciting. It focuses on addressing the source of the pain, rather than solely the treatment," Dr. Tory McJunckin was quoted as saying. "As an interventional pain doctor I have seen incredible advances in the specialty during the past 10 years - and this study shows we are still at the tip of the iceberg for major advances in pain medicine." (Source: http://www.prweb.com/releases/2011/10/prweb8917784.htm)
Bottom of Form
FOR MORE INFORMATION, PLEASE CONTACT:

Tory L. McJunkin, MD
Principal Investigator
Arizona Pain Specialists
1-855-245-6174
Questions@AZStemCell.com

If this story or any other Ivanhoe story has impacted your life or prompted you or someone you know to seek or change treatments, please let us know by contacting Céline McArthur at cmcarthur@ivanhoe.com.


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