Autism clues: Seeing inside the brain

More than two million Americans have autism, and studies suggest that rates will increase 10 to 17 percent each year.

Now, researchers are getting closer to understanding the mysterious disorder – one brain at a time.

It will affect one in every 88 children, but autism has no known cause and no cure.

Researchers at the University of Washington are looking for answers. They have come up with special glasses that measure a toddler's eye contact.

"It records what I’m seeing, so I can see whether a child is looking at my eyes or my mouth," said Wendy Stone, clinical psychologist at Washington.

Scientists are also looking at brain chemistry using MRI.

"Kids with autism have about 10 percent bigger brains than other kids," said Stephen R. Dager, professor of radiology at Washington.

Doctors found between ages three and 10, children with autism and those with developmental delays had significantly less of an important brain chemical.

However, by age 10, the autism group had normal levels but the kids with delays were still low.

Scientists believe this study shows development is not fixed in autism.

"We also found that, in many ways, children bloomed and grew and became really interesting and wonderful people," said child clinical psychologist Annette Estes.

New insights that bring doctors another step closer to understanding a complex disorder.

Researchers are now studying three month old babies who have siblings with autism.

They want to determine if very early alterations in brain cell signaling may precede early clinical symptoms of autism.


REPORT: MB # 3724

BACKGROUND: Autism and autism spectrum disorder are both general terms for a group of complex disorders of brain development. These disorders are characterized by difficulties in verbal and nonverbal communication, social interaction, and repetitive behaviors. Autism begins during early brain development, but symptoms and signs usually cannot be seen until the child is two or three. About 1 and 88 children in the U.S. will develop some form of autism and it is about five times more common in boys than girls. Studies show that 1 in 252 girls and 1 in 54 boys in the U.S. are diagnosed with autism. (Source:
CAUSES: What causes autism? Not long ago, the answer to this question would have been "we have no idea." Researchers are now delivering the answers. First, we now know that there is no one cause of autism. Over the last five years, researchers have found a number of rare gene changes, or mutations, associated with autism. However, most cases of autism appear to be caused by a combination of autism risk genes and environmental factors that influence early brain development. (Source:
NEW TECHNOLOGY: Between ages three and ten, autistic children exhibit distinct brain chemical changes that differ them from children with developmental delays and those with typical development, according to a study at the University of Washington. "In autism, we found a pattern of early chemical alterations at the cellular level that over time resolved - a pattern similar to what others have seen with people who have had a closed head injury and then got better," Dr. Stephen R. Dager was quoted as saying. "The brain developmental abnormalities we observed in the children with autism are dynamic, not static. These early chemical alterations may hold clues as to specific processes at play in the disorder and, even more exciting, these changes may hold clues to reversing these processes." In the study, researchers compared brain chemistry among three groups of children: those with autism spectrum disorder, those with a diagnosis of developmental delay, and those considered typically developing. They used MRI to measure tissue-based chemicals in three age groups: three to four years old, six to seven years, and nine to ten years. An important finding concerned changes in gray matter N-acetylaspartate concentration in scans of the three to four year-olds, concentrations were low in both the autism spectrum disorder and developmentally delayed groups. By nine to ten years, N-acetylaspartate levels in the children with autism spectrum disorder had caught up to the levels of the typically developing group, while low levels of N-acetylaspartate persisted in the developmentally delayed group. (Source:

Annette Estes, Ph.D.
Director, UW Autism Center
Susan & Richard Fade Endowed Chair
Research Associate Professor of Speech and Hearing Sciences
University of Washington

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