Pinpointing prostate cancer: a new way to find it when biopsies fail

About 240,000 men are diagnosed with prostate cancer each year in the U.S.

One of the biggest challenges for doctors is correctly diagnosing this type of cancer.

Now, there's a new way to pinpoint prostate cancer that's more accurate than ever.
Three years ago, Don Buck had a biopsy to check for prostate cancer. It came back clear. A year later - a second biopsy showed no cancer.

But a prior test, known as the PSA, told a different story. Don's levels kept rising. They went up 600 percent in five years! So Don decided to see urologist Leonard Marks to find out if his biopsies could be wrong.

"The conventional way to biopsy the prostate is not a perfect method," explains Dr. Marks.

Traditional biopsies are blind, meaning doctors randomly remove pieces of the prostate in hopes of locating a tumor. Nearly 1 million prostate cancer biopsies are performed each year. Seventy five percent come back negative.

UCLA's Dr. Marks is performing a new, targeted biopsy that's more accurate.

First, patients undergo an MRI. A special device fuses the pictures with real-time 3D ultrasound, allowing doctors to see the lesion during the biopsy.

Leonard s. Marks, md
"Before, we were never able to target like that."

The targeted biopsy showed Don did have cancer and it was aggressive.

“Within two years of the time that I came in to see Dr. Marks, I could have been dead."

In a study published in the Journal of Urology, Dr Marks performed the targeted biopsy on 171 men who either had slow-growing prostate cancer or elevated PSA levels.

Prostate cancer was found in 53 percent of the volunteers.

Of those cancers found using the targeted approach, 38 percent had a Gleason score greater than seven - indicating an aggressive tumor which is more likely to spread.

MEDICAL BREAKTHROUGHS
RESEARCH SUMMARY

TOPIC: PINPOINTING PROSTATE CANCER
REPORT: MB #3696

BACKGROUND: Prostate cancer affects hundreds of thousands of men each year in the U.S. This disease only affects men, but can be very deadly if not caught in enough time. The disease progresses slowly, so slow that doctors may not even catch it until it has taken a life. (Source: http://www.medicalnewstoday.com/articles/150086.php)

RISK FACTORS: There are no known causes of prostate cancer, but there are some risk factors that doctors warn their patients about. Though doctors do not understand the exact cause of prostate cancer, they do know that it is caused by the change in DNA of a prostate cell. Some risk factors of developing prostate cancer can be altered or changed, while others cannot. Risk factors including smoking, diet, weight and STIs can be changed or treated to help prevent the development of prostate cancer but family history, age, race, genes, and nationality are some that cannot be controlled. (Source: http://www.cancer.org/cancer/prostatecancer/detailedguide/prostate-cancer-risk-factors)

SYMPTOMS: Prostate cancer is a slow-moving process, but in its advanced stages, symptoms of prostate cancer can include:

• Blood in urine
• Bone pain
• Erectile dysfunction
• Blood in semen
• Issues in urinating
• Discomfort in pelvic area
• Pain in thighs, lower back, and hips
• Decreased force in stream of urine (Source: http://www.mayoclinic.com/health/prostate-cancer/DS00043/DSECTION=symptoms)

NEW TREATMENT: There is now a new way to determine if a male has prostate cancer. Traditional tests include a biopsy, but almost half of them are wrong. Dr. Leonard Marks from the University of California Los Angeles is conducting a new method to test his patients of prostate cancer. First, an MRI is done to pinpoint the differences in tissue. Then an ultrasound is the next step in the process, and this helps the doctor target the cells that need to be treated. Doctors can then go into the tumor with a needle and determine the size and severity of the tumor. (Source: http://urology.ucla.edu/body.cfm?id=618)

FOR MORE INFORMATION, PLEASE CONTACT:

Kim Irwin
Senior Public Information Officer
UCLA Health Sciences Media Relations
(310) 794-2262
kirwin@mednet.ucla.edu
Patient inquiries: mmacairan@mednet.ucla.edu

If this story or any other Ivanhoe story has impacted your life or prompted you or someone you know to seek or change treatments, please let us know by contacting Marjorie Bekaert Thomas at mthomas@ivanhoe.com


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