Discovery's astronauts are all dressed up in their orange pressure suits, and they definitely have someplace to go--the International Space Station.
The seven crew members are strapped in aboard the space shuttle, waiting to blast off for 14 days in space at 5:02 this afternoon, Eastern time.
Their main mission is to deliver a Japanese science lab the size of a school bus to the space station. But they'll also play plumber, delivering a Russian replacement pump for the station's only toilet, which has been acting up.
The weather is good, and no last-minute technical issues are reported.
Discovery commander Mark Kelly has a twin brother who's also an astronaut. Scott Kelly tells The Associated Press their 91-year-old grandmother always is anxious on launch day. He says she would feel better if they worked at Wal-Mart.