The Southern Michigan Correctional Facility in Jackson County will shut down on Saturday.
The closure of the Blackman Township prison comes nine months after state officials decided to shutter it.
Southern Michigan Correctional has been open in some capacity since 1934.
Michigan Department of Corrections spokesman Russ Marlan tells the Jackson Citizen Patriot the state expects the closure to save about $38 million a year.
All of the 1,400-bed facility's inmates have been lodged at other Michigan prisons.
About 300 prisoners were moved in July. And 606 medically fragile inmates were moved in the last month to facilities throughout the state.
Most remaining employees received word on November 1st of their new assignments in the corrections department.