New vaccines take aim at fighting cancer

Treating cancer could start even before you know you have it.

Cancer vaccines could be the next step in the fight against the most common forms of this deadly disease.

For prostate, breast, and ovarian cancers, there are no cures, but now, there is new hope.

Bud Dougherty is a prostate cancer vaccine patient. He says, "I want to be part of something that works and so people won't die at a young age and can benefit from it."

Bud knows what it is like to face a tough fight. Diagnosed with advanced prostate cancer, he endured surgery and radiation. Now, he's one of the first to use one of two newly FDA-approved vaccines to treat prostate cancer.

Dr. Philip Kantoff of the Dana Farber Cancer Institute says, "We are talking about therapeutic vaccines that treat cancer by revving up the immune system."

PROSTVAC is made up of a small-pox related virus. In a three year study, 30% of patients who received the PROSTVAC vaccine were alive, versus 17% who received a placebo shot.

Meanwhile, another prostate cancer vaccine made from a patient's own cells, called Provenge, improved the median survival rate by ten percent. At The Mayo Clinic, doctors are beginning to test new vaccines targeting a protein that is abundant in both ovarian and breast cancers.

Dr. Keith Knutson of Mayo Clinic says, "It creates memory cells that can be stimulated to destroy a tumor."

At the Cleveland Clinic, researchers are targeting breast cancer before it has a chance to form. This vaccine targets a protein that is expressed in almost all breast cancer, but not in normal breast tissue. The vaccine prevented the disease in 100% of cases in the lab.

These are three vaccines that are taking aim at cancer and saving lives.

The Provenge therapy is being used locally by Dr. Rafat Ansari.

I did a Medical Moment with him and a local teacher using the treatment in September. To read that story, click here.

Meantime, another promising vaccine is targeting lung cancer.

Studies show after surgery to remove the tumor, patients who get the vaccine have a 43% lower risk of recurrence.

RESEARCH SUMMARY

BACKGROUND: Cancer refers to any one of a large number of diseases characterized by the development of abnormal cells that divide uncontrollably and have the ability to infiltrate and destroy normal body tissue. Cancer also has the ability to spread throughout your body, and is the second-leading cause of death in the United States. Cancer is caused by mutations to DNA within cells. Sometimes you're born with a genetic mutation; or they can be caused by forces within your body, such as hormones, viruses and chronic inflammation. Genetic mutations can also be caused by forces outside of your body, such as ultraviolet (UV) light from the sun, cancer-causing chemicals (carcinogens) or radiation. Mutations in oncogenes, tumor suppressor genes and DNA repair genes are the most common ones found in cancer. (www.mayoclinic.com)

RISK FACTORS: Factors known to increase your risk of cancer include: age, environment, health conditions, habits, and family history. (www.mayoclinic.com)

SYMPTOMS: Signs and symptoms caused by cancer will vary depending on what part of the body is affected. Some general signs and symptoms associated with, but not specific to, cancer include: fatigue, difficulty swallowing, persistent cough, indigestion or joint and muscle pain, changes in bladder or bowel, skin and weight changes and a lump or thickening felt under the skin. (www.mayoclinic.com)

VACCINES: Cancer vaccines are medicines that belong to a class of substances known as biological response modifiers. They work by stimulating or restoring the immune system's ability to fight infections and disease. There are two types of cancer vaccines: Preventive (or prophylactic), which are intended to prevent cancer from developing in healthy people; and Treatment (or therapeutic) vaccines, which are intended to treat an existing cancer by strengthening the body's natural defenses against the cancer. The U.S. Food and Drug Administration (FDA) has approved two vaccines, Gardasil(r) and Cervarix(r), that protect against infection by the two types of HPV-types 16 and 18-that cause approximately 70 percent of all cases of cervical cancer worldwide. The FDA has also approved a cancer preventive vaccine that protects against HBV infection, which can lead to liver cancer. In April 2010, the FDA approved the first cancer treatment vaccine. Sipuleucel-T (Provenge(r), manufactured by Dendreon), is approved for use in some men with metastatic prostate cancer. Clinical trials for treatment and preventive vaccines are in progress for several types of cancer including: breast cancer, prostate cancer, cervical cancer, lymphoma, leukemia, lung cancer, pancreatic and kidney cancers, brain tumors, bladder cancer, melanoma, multiple myeloma and solid tumors.

FOR MORE INFORMATION, PLEASE CONTACT:
Tora Vinci
Media Relations
Cleveland Clinic
(216)444 -2412
vinciv@ccf.org


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