Treatment changing lives for people with Ulcerative Colitis

It's embarrassing, it's painful and almost a million people suffer in silence because some are too shy to even tell their doctors. Now, a new treatment is changing people's lives.

Leslie Schwartz hopes what's inside this bag will allow him to enjoy life again.

Leslie Schwartz, Has Ulcerative Colitis, explains how hard he has tried to find a cure, "We've tried just about everything else there is to try."

Leslie has Ulcerative Colitis. That's when ulcers and inflammation form on the lining of the colon and intestine.

He's lived with the uncomfortable symptoms and 10 to 15 trips to the bathroom a day for almost 10 years.

Schwartz explains how uncomfortable it can be, "Very inconvenient because I was bleeding a lot, going to the bathroom a lot."

William J. Sandborn, MD, UC San Diego Health System, explains how many people keep it to themselves, "It's hard to tell your friends what's wrong, and you just kind of have to withdraw from life."

Doctor William Sandborn says patients like Leslie can have surgery, but that means removing the colon and needing an Ileostomy Bag.

Instead, he offered Leslie an experimental therapy.

Sandborn, MD, explains how the treatment is helping, "What we think is happening with this medication is it's promoting healing of that inflamed lining of the bowel."

MDX-1100 works by blocking a protein called chemokine, clearing it from the body, so inflammation can't occur.

Current drugs can hinder the immune system, which can lead to infection and even increase the risk of cancer. MDX-1100 promotes healing.

Sandborn, MD, explains it is helping patients, "It seems to be really targeting the colon, so it leaves most of the rest of the body alone and aims to the colon."

If they stop the therapy, symptoms will come back. Today is Leslie’s first treatment, and he has high hopes.

Schwartz explains what he would like to do the most after the treatment, "I want to go back and play golf, too actually. You know, there's only one restroom between the first and the ninth tee."

A man who's ready to get back to an active life without having an embarrassing problem holding him back.

Patients get an infusion of the drug about every four weeks. So far, it's shown good results in a phase one study. It's now in phase two of testing.

STOP SUFFERING IN SILENCE: HOPE FOR ULCERARATIVE COLITIS
REPORT#1869

ULCERATIVE COLITIS: Ulcerative Colitis is a type of inflammatory bowel disease (IBD) that affects the lining of the large intestine (colon) and rectum. The cause of this disease is unknown. However, patients who have this disease generally have a weaker immune system. Stress and particular foods may trigger symptoms in those who possess this disease. The disease affects all age groups, but there have been peaks at ages 15-30 and then again at 50-70. The disease begins in the rectal area and can grow to infect the entire large intestine.

SYMPTOMS INCLUDE: The symptoms vary in intensity and could start suddenly or slowly. Half of patients experience mild symptoms while the other half gets the worse end. They include:

* Abdominal pain and cramping
* Weight loss
* Blood and pus in the stools
* Fever
* Light or extreme diarrhea
* Joint pain or swelling

AVALABLE TREATMENT:

1. Diet and Nutrition- Certain types of foods may worsen diarrhea and gas symptoms. Eat small amounts of food, drink water, avoid high-fiber foods, limit milk products if you are lactose intolerant, and avoid fatty, greasy or fried foods and sauces.
2. Stress- Stress increases when the disease is active because it results in an increase in the number of bowel movements a day and can be embarrassing.
3. Surgery- Surgery to remove the colon will cure ulcerative colitis and removes the threat of colon cancer. Recommended for patients who have: Colitis that does not respond to complete medical therapy, changes in the lining of the colon that are thought to be precancerous, or serious complications such as rupture (perforation) of the colon, severe bleeding (hemorrhage) (Source: www.ncbi.nlm.nih.gov).

CHANGING LIVES: There are a number of medications available for patients with less severe cases. However, certain drugs can hinder the immune system, increase risk of colon cancer, or lead to infection. But, there is one new drug available that promotes healing, IP-10 or MDX-1100. It works by blocking a protein called chemokine so inflammation cannot occur. The drug has recently been filed with the FDA for approval. Preclinical studies demonstrate that antibodies targeting IP-10 neutralize the effects of IP-10 and decrease the appearance of the disease progression in animal models of ulcerative colitis and inflammatory bowel disease, as well as multiple sclerosis and rheumatoid arthritis. The Phase 2 trial is expected to enroll up to 106 patients at multiple centers internationally. Patients in the study are randomized to receive either placebo or MDX-1100 (10 mg/kg) every two weeks for a total of four doses. The primary endpoint of the study is response rate at eight weeks. (Source: www.drugs.com).

For More Information, Contact:

Jackie Carr
Media Relations
(619) 543-6163
jcarr@ucsd.edu

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