Parkinson's researchers hope to solve diagnosing problem

SOUTH BEND, Ind.--- One million Americans currently live with Parkinson's disease.

Right now there's no way to tell if these patients will have a mild or severe form of the disease, but a simple blood test might change that.

It's giving Parkinson's patients a glimpse into their future.

Michael Weinman has been living with Parkinson's for 14 years now.

"I used to be able to run. I can't run anymore. I used to be able to carry my food to the table. I can't do that," said Michael.

Through all the challenges Michael has kept a positive attitude.

"I try to focus on what I can do though," said Michael.

“He's a glass half full kind of person," said Nesa Weinman, Michael’s wife. (:02)

While Michael's disease has progressed slowly, Parkinsons' patients don't know whether their disease will be mild or severe when they are diagnosed.

"Nobody who is a neurologist and sees patients can very well predict who will rapidly decline and eventually need a wheelchair quite fast," said Dr. Beate Ritz, Department Chair of Epidemiology at the Center for Occupational and Environmental Health.

Dr. Ritz and colleagues studied recently diagnosed Parkinson's patients. They took blood samples and found those with higher levels of a Metabolite -N-8-Acetyl Spermidine declined much faster than those with lower levels.

"We found that this one metabolite seemed to really distinguish these two groups from each other," said Dr. Ritz.

Doctors say the next step is to conduct a larger study on this metabolite as a predictor of faster progression.

Michael and his wife hope research like this will help others. They walk in the annual "Mike-Hike" which has raised more than $40,000 for Parkinson's research.

"Hopefully in the future, they'll be able to treat it and recognize it sooner," said Michael.

MEDICAL BREAKTHROUGHS
RESEARCH SUMMARY

TOPIC: DEATH CALCULATOR: PREDICTING HEART FAILURE
REPORT: MB # 3778

HEART ATTACKS: More than a million Americans have heart attacks a year. The heart muscle needs a constant supply of oxygen-rich blood to nourish it. The coronary arteries provide the heart with blood supply. Coronary artery disease causes the arteries to narrow and blood will not flow properly. Fatty matter, proteins, calcium, and inflammatory cells build up within the arteries to form plaques of different sizes. The plaque deposits are hard on the outside and soft on the inside. When plaque is hard, the outer shell cracks and platelets come to the area, and blood clots form around the plaque. If a blood clot totally blocks the artery, the heart muscle becomes "starved" for oxygen. Over time, death of heart muscle cells occurs, causing permanent damage. This is a heart attack. (Source: www.webmd.com)
DR. CADERIAS: "Heart disease is all about fluid. It's the heart not being able to perform well; it's too weak, so fluid backs up, for example to the lung or to the circulation and then accumulates inside the body. The other variable that is included in this score is whether the patient is on a specific medication. This medication is called an ACE inhibitor or an angiotensin receptor blocker. The fact that the patient is on that medication is good because it is linked to patients doing better over time; the fact that the patient is not on that may be an indicator the patient is worsening or is doing poorly. The third variable is what we call near heart association functional class that basically grades the degree of shortness of breath. Patients with heart failure have shortness of breath which is a manifestation of fluid that backs up to the lungs and the more shortness of breath that you have, the higher that score. The fourth variable is a little bit more complex to explain, but it's basically related to how we perform given exercise. An analogy can be when we get our car to measure the gas every year or every so often to see how the engine is working, so the emissions in the car are way of judging how our car is doing in general. And in the body is about the same. How well our heart is performing we can measure with a mask and the result of that evaluation we can plug it into the score as well. This is called cardiopulmonary exercise test and the result of that test is the fourth variable of this score."
FOR MORE INFORMATION, PLEASE CONTACT:

The Ahmanson-UCLA Cardiomyopathy Center
(310) 825-8816
http://transplants.ucla.edu/body.cfm?id=111&oTopID=31/


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